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Intravenous administration of lipoic acid at doses of 600 mg/day for three weeks (112) and oral lipoic acid at doses as high as 1,800 mg/day for six months (113) and 1,200 mg/day for two years (76) did not result in serious adverse effects when used to treat diabetic peripheral neuropathy
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These formulations are used off-label in specialized clinics, not sold as over-the-counter products
In addition, an imbalance between the decreased astroglial kynurenic acid and the increased microglial quinolinic acid has been shown in PD (75)
36 , e2310576 (2024)
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