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NMN is well tolerated in healthy participants who received 300, 600, or 900 mg per day for a total of 60 days 322,323 , with all NMN doses increasing blood NAD + levels, and no adverse events were observed
After opening commercial serum Once opened (seal broken): Air exposure begins Bacterial contamination possible Oxidation accelerates Shorter shelf life Track opening date Shelf life after opening: Why packaging matters: Airless pump: Minimal air contact, longest life Dropper: Some air exposure, moderate life Jar: Maximum air exposure, shortest life Finger contamination risk (jar) Best practices after opening: Refrigerate after opening (extends life) Close tightly after each use Don't contaminate (no fingers in product) Use within 6 months ideally Note opening date on bottle Signs commercial serum degraded: Color change (darkening, blue-green tint) Smell change (rancid or off odor) Texture change (separation, clumping) Reduced efficacy (no longer works) Irritation (preservatives depleted, bacteria) When to discard: Past expiration date + 3-6 months opened Any signs of degradation above Unusual smell or color Product separated and won't remix Skin irritation develops Commercial vs DIY serum stability Commercial serum advantages: Professional preservative systems pH buffered correctly Antioxidants included Tested stability (12-24 months unopened) Quality assurance DIY serum challenges: No professional preservatives (or inadequate) pH optimization difficult Limited antioxidant protection Short shelf life (1-2 weeks refrigerated) Bacterial contamination risk Comparison: When DIY acceptable: Make small batches (1-2 weeks supply) Use immediately Refrigerate always Accept short shelf life Understand contamination risk When commercial better: Want convenience Need longer shelf life Travel frequently Don't want frequent preparation Value safety/stability See DIY GHK-Cu serum recipe for home formulation
More specifically, they both appear to upregulate the production of growth hormone
Retinol Rapid Repair & Dark Spot Treatment: Water, Niacinamide, Simmondsia Chinensis (Jojoba) Seed Oil, Polyacrylamide, Kojic Acid, C13-14 Isoparaffin, Phenoxyethanol, Retinyl Palmitate, Laureth-7, Tocopherol, Retinol, Polysorbate 20, Sodium Metabisulfite, Ethylhexylglycerin, Citric Acid, Sodium Phytate, Squalane, Tetrahexyldecyl Ascorbate, Glycerin, Alpha-Arbutin, Ascorbic Acid, Glutathione, Azelaic Acid, Alchemilla Vulgaris Flower/Leaf/Stem Extract, Malva Sylvestris (Mallow) Flower/Leaf/Stem Extract, Mentha Piperita (Peppermint) Leaf Extract, Primula Veris Flower Extract, Veronica Officinalis Flower/Leaf/Stem Extract, Melissa Officinalis Leaf Extract, Sodim Sulfite, Sodium Hyaluronate, Achillea Millefolium Flower/Leaf/Stem Extract
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