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Perhaps in the future, they can also serve as effective thickeners, where the rheological properties of the solution can be changed by the shape factor of the amyloid fibres without changing the mass or caloric content of the food [180]

More recently, the SUMMIT trial demonstrated that tirzepatide reduced the composite risk of cardiovascular death or worsening heart failure by 38% (HR = 0.62, 95% CI: 0.410.95) in patients with heart failure with preserved ejection fraction (HFpEF) and a BMI 30 kg/m 2 , 32% of whom also had type 2 diabetes