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It aims to dissect the molecular pathways, evaluate the animal model data, and critically assess the state of human research to equip clinicians with a balanced and actionable perspective

doi: 10.1016/j.intimp.2006.08.001 37 KawanishiYTominagaAOkuyamaHFukuokaSTaguchiTKusumotoYet al

Both are copper-binding tripeptides, but they have different amino-acid sequences

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When these isolated senescence cells were presented with FOXO4-DRI peptide, researchers reported that the peptide appeared to block FOXO4 proteins, allowing p53 to bind with DNA, which led to the nuclear exclusion of p53 and induction of apoptosis of the senescent Leydig cells