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Mice with loxP sites flanking the fifth TR exon (TR Floxed mice), developed by Shanghai Model Organism Center, Inc., were fertile and appeared indistinguishable from TR +/+ mice

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Brain Sciences (2021) This study by an independent research group (outside the original Washington State University team) demonstrated that Dihexa rescues cognitive impairment in an Alzheimer's disease mouse model (APP/PS1 transgenic mice)

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