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In addition, vascular endothelium also plays a central role in maintaining blood flow, regulating platelet adhesion and aggregation, leukocyte activation, adhesion and transport, and precisely balancing coagulation and fibrinolysis systems, profoundly affecting the dynamic balance of immune response, inflammation regulation and angiogenesis (Krger-Genge et al., 2019)
Comprising SLC7A11 and SLC3A2, system xc - functions as a cystine/glutamate antiporter that brings extracellular cystine into cells while exporting intracellular glutamate (188, 191)
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