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doi: 10.1016/j.bbrc.2010.12.077 71 NakamuraTTanimotoHMizunoYTsubamotoYNodaH

Stop taking XIGDUO XR and call your healthcare provider right away if you have any of the following symptoms, which could be signs of lactic acidosis: you feel cold in your hands or feet you feel dizzy or lightheaded you have a slow or irregular heartbeat you feel very weak or tired you have unusual (not normal) muscle pain you have trouble breathing you feel unusual sleepiness or sleep longer than usual you have stomach pains, nausea or vomiting Most people who have had lactic acidosis with metformin have other things that, combined with the metformin use, led to the lactic acidosis

No dosing or regimen recommendations are provided or implied

Akiko Sato (Kyushu University, Japan) for technical assistance concerning animal care and satellite-cell culture experiments

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