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Symptoms of low blood sugar may include dizziness or light-headedness, sweating, shakiness, blurred vision, slurred speech, weakness, anxiety, hunger, headache, irritability or mood changes, confusion or drowsiness, fast heartbeat, feeling jittery
These may include nausea, increased appetite, weight gain, and cardiovascular changes, like elevated blood pressure
The ATTAIN-MAINTAIN data shows this transition is feasible with minimal weight regain, particularly for patients who were previously on semaglutide and even for those on tirzepatide (with modest regain of approximately 5 kg)
Several mechanistic studies suggest that GLP-1 receptor activation enhances sympathetic activity or reduces vagal tone
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