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Study participants did not have a prior diagnosis of epilepsy or seizures
In pivotal studies, patients using semaglutide (Wegovy) lost an average of 15% of their body weight over 68 weeks
During semaglutide therapy, many patients experience marked decreases in appetite and early satiety, which can lead to reduced overall food intake
However, since long-acting GLP-1RAs like liraglutide and semaglutide have little effect on gastric emptying, this seems unlikely to be the mechanism by which all GLP-1RAs reduce energy intake and mediate weight loss (140)
