Most GI side effects resolve within 48 weeks at each dose level as GLP-1 receptors adapt
Delayed gastric emptying extends the time B12 spends in the acidic stomach environment, which might initially seem beneficial
For an intramuscular shot that goes deep into the muscle (like in the arm or buttocks), a longer, slightly thicker needle is needed to reach the target
The tirzepatide dose groups and regimens were as follows: 12 mg (4 mg for weeks 0-3, 8 mg for weeks 4-7, and 12 mg for weeks 8-11), 15 mg-1 (2.5 mg for weeks 0-1, 5 mg for weeks 2-3, 10 mg for weeks 4-7, and 15 mg for weeks 8-11), and 15 mg-2 (2.5 mg for weeks 0-3, 7.5 mg for weeks 4-7, and 15 mg for weeks 8-11)
Even with direct-to-patient access programs that recently lowered the cost of some injectable GLP-1s to $499 a month, the cost can be too much for some users