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Ozempic is approved for type 2 diabetes management at doses of 0.5 mg and 1 mg (up to 2 mg), and is associated with cardiovascular risk reduction in high-risk patients
Exercise significantly benefits individuals with T2DM by enhancing insulin sensitivity and glycemic control [230] and can prevent or delay T2DM onset [231]
Practical considerations also differ, with GLP-1RAs requiring gradual titration to mitigate gastrointestinal adverse effects, while SGLT2is are typically initiated at therapeutic doses with dose adjustment as needed based on kidney function
Wallach JD, Krumholz HM
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