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The GBA [100, 301, 350] provides an essential link between two important systems of the nervous systemnamely, the CNS and the enteric nervous system (ENS), and the gut microbiome and metabolome [440]

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Research shows that patients on GLP-1 therapy experience metabolic adaptation within weeks of starting treatment, shifting their set point for temperature regulation downward

There it can help regulate nuclear gene expression that supports metabolic homeostasis

HbA1c improvements should be approaching their maximum effect