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BM cells were harvested from C57BL/6 donor mice that had been pre-treated with 5-fluorouracil (5-FU) five days prior
By whole-hippocampus RNA-seq they observed that the knockout of TLX upregulates 1272 genes, compared to wild-type, of which 1096 are implicated in cell chemotaxis ( Cxcr2 , IL17RA , Cxcl10 , Fgf2 , Cxcl5 , Ccl9 , Ccr1 , Cxcl13 ) and 176 are in common with genes increased in wild-type mice injected with IL-1 into the hippocampus and are implicated in cell response to cytokine stimulus ( Nfkbia , IL6 , Cxcl1 , Ccl2 )
The strongest human evidence is topical, including the Leyden 2002 photoaging trial and a 2023 IRB-approved 21-woman topical NEEL gel study reporting an average 28% increase in skin collagen density at 3 months
However, these studies are still limited to lab only, and cant be directly applied to human use
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