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On the other, a potent, centrally-acting agent that re-engineers appetite signaling

Combination GABA with GAD immunization increased the duration of syngenic -cell survival in diabetic NOD mice from 1 week in control-diabetic mice to 10 weeks with maximal GABA doses (GABA 6 ml/ml in drinking water + 100 mg GAD immunization) ( Finally, in severely diabetic NOD mice, low-dose anti-CD3 (35 mcg) and lesgaberan, a GABA-B receptor agonist (0.08mg/ml in drinking water), rapidly lowered blood glucoses and preserved functional -cells over a 25-week treatment period ( Notably, GABA has shown anti-diabetic actions in diverse T1D rodent models, including NOD mice, multiple low dose STZ mice as well as humanized rodent models such as the NOD/Lt-SCID-IL2rg or NSG mouse ( 2.3 GABA promotes -cell proliferation and survival Loss of -cell mass due to a reduction in -cell proliferation/regeneration and accelerated -cell apoptosis are synergistic processes leading to the clinical manifestations of TID

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These compounds have also demonstrated anti-inflammatory, antioxidant and renoprotective activity [69]

doi: 10.1001/jama.2023.19574 15 ZhengZZongYMaYTianYPangYZhangCet al