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In particular, LC3B and SQSTM1, two major autophagy regulators, are significantly upregulated alongside increased GFAP expression

For those managing CKD, excess weight forces the kidneys into a state of hyperfiltration, increasing glomerular pressure and accelerating the scarring of delicate tissues

Although Truveta Data is updated daily, we only used data through December 2024 as the last month of this analysis to allow for the 100-day prescription window