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The peptide appears to activate genes associated with tissue remodeling while suppressing genes linked to inflammation and tissue breakdown
Endocrinology 2011;152:4072-9.ArticlePubMed 96
The same phenomenon was observed for Met464 residue in EcGGT (Met462 in BlGGT) wherein M464E and M464K were maturationally blocked mutants, while M464L exhibited no loss in autoprocessing but had a 50% loss in activity (Lo et al., 2007)
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