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Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity
Mechanistically, it acts as a ghrelin mimetic, binding the growth hormone secretagogue receptor (GHS-R1a) the receptor for the endogenous peptide ghrelin, expressed in the pituitary and hypothalamus
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[4] [3] A major reason hypothyroid patients need closer monitoring on GLP-1 therapy is that weight loss can alter thyroid hormone requirements