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In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability [2]
That is why AOD-9604 is best thought of as targeted support rather than a heavy hitter, and why PeRx often pairs it with MOTS-c
[48] What the nursing mother consumes is more important than her liver tissue content, as it is recently absorbed vitamin that more effectively reaches breast milk
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