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M2-like (or homeostatic) states help preserve neurons by removing extracellular -synuclein fibrils, releasing neurotrophic factors like BDNF (brain-derived neurotrophic factor) and GDNF (glial cell linederived neurotrophic factor), encouraging synaptic repair, boosting glutamate uptake via EAAT2, and creating anti-inflammatory cytokines like IL-10 and TGF-
Ultimately, exendin-4 may play role as a novel treatment of NAFLD via direct effect on hepatic lipid and glucose metabolism
2011 Feb;14(1):4-10
These medicines have also yielded meaningful benefits for obese individuals who were unable to achieve adequate weight reduction through lifestyle modifications
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