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Description

Only specific small molecules and some substances produced by special transport proteins or receptors can enter the brain through the blood-brain barrier

Rapid enrollment poses unique operational challenges to sites, sponsors, and contract research organizations (CROs)

L.JedlickaA.TuragaN.FolawiyoO.PiriniF.et al (2016)

The exclusion has been the rule for over two decades and applies regardless of BMI, comorbidities short of an FDA-approved non-weight-loss indication, or out-of-pocket hardship