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Glucagon receptor agonists carry a theoretical (though unconfirmed in humans) thyroid C-cell concern
Some patients also dropped out because they lost too much weight
Genetic variants in GIPR and FTO, and MC4R pathways correlate with differential treatment outcomes across injection, oral, and emerging transdermal formulations
As of 2025, most large employers did not cover GLP-1 drugs for weight loss
Kaufman emphasized that the results are not uniform as always, its a subset that responds
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