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exposed HepG2 cells to 520 M TSN for up to 24 h and showed a 15% loss of cell viability that correlated with partial GSH depletion, a three-fold increase in LPO, and reduced GPx4 expression
Blood 82(10 Suppl 1):89a, 1993
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In contrast, genes regulating cell cycle ( Ptp4a2, Gtpp4, Tbrg1 ) and translation initiation ( Eif1ad ) exhibited increased translation efficiencyunderscoring the complex interplay of hypoproliferative and hyperproliferative signals present in Rps15 -mutated cells well in advance of leukemic transformation
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