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Its upregulation of antioxidant enzyme expression, including superoxide dismutase and catalase, has also been a subject of research interest

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When mast cells are over-activated, it can lead to an exaggerated response in the body and a wide range of symptoms, and through this link to hormones they can affect the heart rate/blood pressure and a cascade of other effect of the sympathetic nervous system including POTS (Postural Orthostatic Tachycardia Syndrome)

Ethics declarations Competing interests RS and JPR received research funding for this study from Researched Nutritionals, LLC

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells