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The modulatory effects of combined therapy with GLP-1RAs and other drugs on tumor risk As GLP-1RAs continue to see expanding clinical application, it is imperative that clinicians give careful consideration to the potential adverse effects linked to combination therapies

These agents have a beneficial effect on pancreatic islet function by facilitating the secretion of insulin in response to ambient blood glucose levels and inhibiting glucagon secretion both directly and indirectly

and a distributed network fanning out from the midbrain to the prefrontal cortex orchestrates reward elements

Presented for research literature review only Deanfield J et al

Interestingly, there was no correlation between the positive effect on glycemic control and an increased risk of hypoglycemia [73]