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Acknowledgements We acknowledge the use of cryo-EM facilities at the Advanced Center for Electron Microscopy, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

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330 CAF-derived cytokines (e.g., IL-10, IL-6, CCL2) recruit and polarize macrophages into immunosuppressive M2-TAMs, which secrete TGF- and IL-10, suppressing cytotoxic T-cell responses and facilitating immune escape