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The Febs Journal, 283 , 44134423

It could also cause adverse effects

IGF1R activation via DES(1-3) IGF-1 induced a 2.8-fold increase in S-phase cell population, reversing the 50% S-phase reduction produced by gefitinib monotherapy

Its also important to avoid having a high level of reverse T3, which is a molecule related to T3 that blocks thyroid receptors in cells instead of activating them