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References Ng M, et al
Avgerinos, K
The researchers projected that the participants would return to their original weight in 18 months
Insulin is the dominant metabolic hormone controlling glucose and lipid homeostasis, such that humans or mice with insulin deficiency or mutations of the IR develop severe hyperglycemia and uncontrolled lipolysis (810), whereas animals lacking IGF-1 or with mutations in IGF1R display severe growth deficiency both prenatally (11) and postnatally (12, 13)
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