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Significant weight regain during the switch is unlikely because the overlapping pharmacokinetics of both medications prevent a complete gap in appetite suppression

Average weight gain after discontinuation was 2.03 kg, and HbA1c levels rose, even as fasting plasma glucose remained largely stable

The TRIUMPH Phase 3 Program: All Current Trials Eli Lillys TRIUMPH program is one of the most comprehensive Phase 3 programs in obesity drug history, enrolling over 5,800 participants across multiple trials: Sources: ClinicalTrials.gov

Cognitive Function: Adequate B12 levels are linked to improved memory and reduced risk of cognitive decline

For gastrointestinal side effects: Eat smaller, more frequent meals rather than three large meals daily Avoid high-fat, greasy, or spicy foods , which may exacerbate nausea and slow digestion further Stay well hydrated , sipping water throughout the day, particularly if experiencing diarrhoea or vomiting Eat slowly and chew thoroughly to reduce feelings of fullness and discomfort Avoid lying down immediately after eating