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McCommis et al., 2015
Brain 114:775788
If efficacy favors tretinoin, tolerance decisively favors GHK-Cu and for many people, tolerance is what determines whether a product is actually used long enough to work
Based on the phenomena directly observed in the OA model, the mechanisms verified in other chronic inflammatory/degenerative diseases [such as rheumatoid arthritis (RA)], and reasonable inferences based on the cross-linkages of molecular pathways, we propose a hypothetical framework, suggesting that the gut microbiota-ferroptosis axis ma contribute to the progression of OA and explore the therapeutic potential of synergistic intervention measures targeting this axis
By molecular simulation, we have previously shown that YMU1 acts on the catalytic pocket of TMPK, which causes the expulsion of the lid domain to give an open conformation that inhibits the catalytic process 19
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