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Main Phase (Baseline to Week 26): Study 1 This study randomized 412 HIV-infected patients with lipodystrophy and excess abdominal fat to receive either tesamorelin (N=273) or placebo (N=137)
Animal studies have shown both anxiolytic and anxiogenic effects of GLP-1 receptor agonists, depending on the brain region and the receptor subtype involved
Patients at greatest risk of this reaction are those with impaired renal function, heart failure, liver dysfunction, those using diuretics concomitantly and the elderly
doi: 10.3389/fendo.2022.810242
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