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Apoptosis signal-regulating kinase 1 (ASK1) is a serine/threonine protein kinase and activates JNK and p38 pathways

The existing MetS-associated animal models induced by high-fat diets are mainly rodent models, including (diabetic ED rats, hyperlipidemic ED rats, etc.), which may only lead to obesity or insulin resistance, but lack key manifestations such as hypertension or inflammation

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