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Indeed, carcinogenicity studies in rats and mice have demonstrated a dose- and time-dependent increased risk of medullary thyroid carcinoma (MTC) with GLP-1 RAs [11,12]
Based on animal reproduction studies showing fetal harm at clinically relevant exposures, the FDA recommends that semaglutide should be discontinued at least 2 months before a planned pregnancy due to its long washout period (approximately 5 weeks after the last dose)
In some cases, slowed intestinal motility may lead to small intestinal bacterial overgrowth (SIBO), further contributing to bloating and gas
People who took GLP-1 for about three years without interruption experienced the greatest cardiovascular benefits: the risk of heart events declined by about 18% compared with those taking sulfonylureas
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