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A comprehensive metabolomics and transcriptomics study investigating bioenergetics, including brain and plasma acylcarnitines, in 16 months old APOE3-TR and APOE4-TR mice found increases in FAO in E4s especially in females (Shang et al., 2020)
Daily observations: Appetite level (1-10 scale), nausea level (0-5 scale), energy level, any notable GI symptoms, bowel changes, mood or sleep changes
BGB 16673 for CLL and SLL demonstrates how therapies developed for resistant or narrowly defined populations can serve as lifecycle expansion platforms
The transition has not been clean
Even before approval, we typically start discussions to determine what our approach will look like and begin to build our strategy. Its important for us to stay ahead of the curve and develop a strategy around availability and cost
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