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QMP engineering prolongs the ability of the GLP-1 albumin fusion to restrict glycemic excursion in vivo To investigate whether the GLP-1 albumin fusions would stimulate insulin secretion in vivo, we performed a glucose tolerance test (GTT) in human FcRn Tg32 mice (Fig
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In addition to improving insulin resistance, a hypothesized mechanism in the progression of PD, in vitro and in vivo studies have shown that GLP-1 RAs can inhibit many pathways present in the pathogenesis of PD
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