Because of the glucagon component, it also caused an increased heart rate in some participants
Potential Causes of Allodynia Allodynia is associated with several neurological and metabolic conditions, including: Peripheral Neuropathy (due to diabetes, chemotherapy, or autoimmune disorders) Fibromyalgia (central pain sensitisation disorder) Migraine Disorders (involving trigeminal nerve hypersensitivity) Neuroinflammation and Immune Dysregulation (as seen in post-viral syndromes) Medication Side Effects, including possible links to GLP-1 receptor agonists Mechanisms: How GLP-1 Medications May Contribute to Allodynia GLP-1 receptor agonists (e.g., Mounjaro, Wegovy) are widely used for weight loss and glycemic control due to their role in glucose-dependent insulin secretion and appetite suppression
Cusi K, Sattar N, Garca-Prez LE, Pavo I, Yu M, Robertson KE, et al
Its found in many laxative supplements, including Ex-Lax and Senokot
Kimborough CK, Griffiths CE, Finkel LJ, Hamilton TA, Bulengo SM, Ellis CN