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First, a bacterial reverse mutation test (Ames test) assessed AOD9604s mutagenic potential using four histidine-dependent auxotrophic mutants of Salmonella typhimurium (TA1535, TA1537, TA98, TA100) and one tryptophan-dependent auxotrophic mutant of Escherichia coli (WP2 uvrA), using both plate incorporation and pre-incubation methods at doses of 0, 1.6, 8, 40, 200, 1,000, and 2,000 g AOD9604/plate

The longest published human exposure is 12 months of sermorelin in diagnosed children, and 7 days of intravenous ipamorelin in surgical patients

Van De Walle, Gavin

doi: 10.1186/s13601-020-00362-7 26 BrandesR

Interestingly, all other tested pathways (oxidative stress, DNA damage, and inflammatory stress) were not significantly activated by either AQ-QI or DEAQ-QI treatment (Supplementary Figure S5)