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JAM-C can maintain the EC in a polarized manner, creating a unidirectional gate for neutrophil movement from the vascular lumen to the proximal tissue compartment, whereas the effects of NE and certain acute inflammatory conditions, such as ischemia-reperfusion injury, may impair this gate by downregulating the expression of JAM-C

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A binary hierarchical cluster tree was then constructed using the color_branches function, which relies on the cutree function from the R package dendextend

About this article Cite this article Zelniker, T.A., Braunwald, E