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Absolute deficiency occur up to 6% of those aged 60 years and older, whereas marginal deficiency occur in close to 20% of patients in later life ( Pernicious anemia is an autoimmune gastritis resulting from the destruction of gastric parietal cells and consequent impairment of intrinsic factors secretion to bind the ingested vitamin B12
A lack of intrinsic factors becomes more common with age, and is linked with pernicious anaemia an autoimmune condition that affects the stomach
Its also worth noting that highly concentrated solutions may irritate the injection site
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