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For extended periods, storage at 20 C is recommended
Acquired resistance often originates from preexisting heterogeneity within the tumor and is further shaped by continuous diversification during therapy, enabling certain subclones to survive therapeutic pressure and eventually emerge as dominate resistant phenotypes
CDC summarizes that guidance directly in its injection safety recommendations: "Once a multi-dose vial is opened (e.g., needle-punctured) the vial should be dated and discarded within 28 days unless the manufacturer states another date for that opened vial
Stay away from direct sunlight and excessive heat immediately after treatment
Smullin DH, Skilling SR, Larson AA
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