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GLP-1
The mechanism by which semaglutide provides cardiovascular protection likely involves multiple pathways, including weight reduction, improved glycemic control, and blood pressure lowering
The GLP-1 component works by stimulating insulin secretion when blood sugar rises and suppressing glucagon release
The fact that TMV-infected tobacco lines expressing nahG display elevated induction of PR-1 genes at 5 DAI is in line with recent results, showing enhanced expression of NtPR-1b and NtPR-1c in NahG tobacco in later stages of TMV infection (7 DAI) as compared to wild type (Gullner et al., 2017a)
No direct head-to-head maintenance trial exists, but indirect evidence favors tirzepatide
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