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Beta-3 adrenergic receptor pathway studies, where Heffernan et al
The increase in UA following uricase knockout resulted in attenuation of behavioural and neurochemical pathology, while animals overexpressing this gene showed an enhancement of these measures
NAC has slightly better bioavailability than standard glutathione, but it still faces challenges
Further investigation into expanding payload diversity to overcome resistance mechanisms is also warrantedespecially since current ADC payloads primarily fall into three main classes while many other classes of cytotoxic agents still remain 250
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