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However, chronic low intake combined with rapid weight loss may increase long-term bone turnover risk if nutritional adequacy is not maintained

doi: 10.1016/j.abb.2016.04.014 18 CostelloLCFranklinRB

Breastfeeding and Pregnancy : Although there is little information on the safety of astaxanthin during pregnancy and nursing, it is advisable for these women to avoid taking supplements containing astaxanthin until more research is available

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A 41-day phase 2a study in participants with controlled T2D and BMI 2740 kg/m 2 shows a mean weight loss of 4.0% in those administered cotadutide with a target dose of 200 mcg daily, compared to 1.7% for the placebo group (100)