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IV delivery places the administered dose into systemic circulation, but that does not mean 100% enters target cells, remains intact, reaches a specific organ, or produces a clinical benefit
Cell line-specific responses were also reported for gliomas [101], only demonstrating SST upregulation upon 5-AZA-dC treatment in cell lines characterized by promotor hypermethylation
Caffeine can cross the placenta, so caffeine intake from coffee, soft drinks, energy drinks, and teas should be limited to under 200 milligrams a day (the equivalent of 10 oz
10.1017/S0007114521005201 12
JAMA psychiatry 77 (12), 12461255
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