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The authors reported the following findings: The mean change in the KCCQ-CSS was 16.6 points with semaglutide and 8.7 points with placebo (estimated difference, 7.8 points), and the mean percentage change in body weight was 13.3% with semaglutide and 2.6% with placebo (estimated difference, 10.7 percentage points)

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Gastrointestinal Side Effects Although studies on GLP-1 RAs clearly demonstrate substantial clinical benefits, their short- and long-term safety profiles have not yet been fully elucidated

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Unlike commercial insurance that can choose whether to cover weight loss medications, Medicare Part D's weight-loss exclusion is mandated by statute

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For example, in a 68-week clinical trial, semaglutide users experienced an average weight loss of 15.8%, with 86% of participants achieving clinically meaningful results

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