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doi: 10.1073/pnas.95.14.7987 115 HuangY.-H.ShihC.-M.HuangC.-J.LinC.-M.ChouC.-M.TsaiM.-L.et al
Let's clear up a few of the most common misconceptions
Q.23 Administration of primaquine causes severe hemolytic anemia because it (A) increases the demand for NADPH to a level that cells cant meet (B) decreases the demand for NADPH (C) inactivates glutathione peroxidase of erythrocytes (D) increases reduced glutathione level of erythrocytes Primaquine administration causes severe hemolytic anemia primarily in individuals with G6PD deficiency due to oxidative stress overwhelming cellular defenses
It does not replace any of them
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