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Cyanocobalamin, a slightly toxic, synthetic form, is especially dangerous to pernicious anemia patients

acknowledges funding from the Royal Society for his University Research Fellowship, funding from the ESIWACE2 project (EU Horizon 2020 under grant no

Quick Reference: Standard Protocol Community-documented protocol: 250 mcg subcutaneous in the morning, 3 days per week, for 8-week cycles -- far below the 2.4 mg weekly clinical trial dose, reflecting conservative research-peptide practice

Experimental approaches include behavioral testing (Morris water maze, novel object recognition), electrophysiology (LTP recording), neurochemical analysis, imaging techniques (PET, MRI), and various neurotoxin or transgenic disease models