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Recent studies have suggested that ASD is associated with impairments in basic physiological processes such as redox (16) and mitochondrial (9) metabolism as well as abnormalities in regulating essential metabolites such as folate (17), tetrahydrobiopterin (1820), glutathione (2123), cholesterol (24), carnitine (2528), and branch chain amino acids (29)

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Of note, glycemic control improved with HbA1c reductions reaching 0.8% with survodutide therapy, indicating preserved glycemic benefits despite GCG agonism, likely reflecting the predominant GLP-1 receptor activity ratio

It is a coherent rationale