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A variety of diseases, such as sickle cell anemia, thalassemia 38 , malaria 39 , and diabetes 40 , can impact RBC deformability 41,42

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This study aims to pinpoint genetic causes of ME/CFS by testing more than 25,000 DNA samples (586), as a large cohort will help achieve statistical power with reproducible and rigorous results (52)

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Biosolve B.V), shaken for 15 min, centrifuged at 10.000 g for 10 min, and 40 l of each individual sample transferred to a glass vial with a micro glass insert