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This could be associated with the damage to cell component, basement membrane and epithelia by lipid peroxidation, protein denaturation and enzyme inactivation in vascular endothelial cells

Microchem J 177:107283 Lai X, Shen Y, Gao S, Chen Y, Cui Y, Ning D, Ji X, Liu Z, Wang L (2022) The Mn-modified porphyrin metal-organic framework with enhanced oxidase-like activity for sensitively colorimetric detection of glutathione

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It is believed that the CblC protein, or the Methylmalonic aciduria and homocystinuria type C protein (MMACHC), catalyzes the first step in converting inactive vitamin B12 forms into active forms like methylcobalamin or 5-adenosylcobalamin