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The dependence of tyrosine hydroxylase on BH 4 necessitates the coupling to the action of dihydropteridine reductase (encoded by the QDPR gene: quinoid dihydropteridine reductase) as is the situation for tryptophan hydroxylase (see below) and phenylalanine hydroxylase
Metformin improves insulin sensitivity and liver function, producing modest indirect weight loss
By contrast, PG-102 markedly preserved -cell area and islet architecture, consistent with its robust glycemic effects (Fig
doi:10.1016/j.pmrj.2011.03.008 40GilronI, BaileyJM, TuD, HoldenRR, JacksonAC, HouldenRL
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